All photography provided by Amr Kataya

we seek to establish knowledge on signaling through post-translational modification by phosphorylation in the organelle, peroxisomes.

 

Our target

Peroxisomes are involved in the metabolism of various biological components as lipid metabolism. Peroxisome malfunctions have detrimental effects on development and are linked to several inherited diseases in humans. My research interests are specifically directed towards the unknown regulatory mechanism of peroxisome functions by phosphorylation. Currently, we shaped a framework to study peroxisomal regulation by phosphorylation and interaction with other organelles. Our research includes basic research and we are, stepwise, heading towards applied research.


Learning is a matter of gathering knowledge; wisdom is applying that knowledge
— Dr. Roopleen

What We've Achieved

  • We have cataloged over 100 polypeptides as peroxisomal phospho-proteins using available phospho-proteomic datasets, fully establishing protein phosphorylation as a regulatory mechanism in peroxisomes (Kataya et al., 2019).

  • exploring a role for PP2A in peroxisomal beta-oxidation process

  • Identification of several novel peroxisomal protein phosphatases

  • Studying the PP4 catalytic and putative regulatory subunits

  • Investigation of the role of methylation on PP2A function

  • Validations of multiple novel peroxisomal signals and proteins

  • Validation of novel peroxisomal proteins implicated in innate immunity

  • Exploring indications for two novel pathways for importing proteins into peroxisomes

  • Detection and sequencing of ToCV virus

  • Identification of two RNA silencing suppressors from two viruses